This study identifies and evaluates antibacterial activity of novel 4,5-dihydro-1H-pyrazole derivatives, suggesting potential applications in combating gram-positive and gram-negative bacteria.
In this work, a series of new 4,5-dihydro-1H-pyrazole derivatives (M21-M25) has been synthesized successfully via the reaction of different aldehydes with ketones to produce chalcones, followed by the reaction with hydrazine and phenyl hydrazine. The prepared compounds were identified using FT-IR spectroscopy, 1H NMR spectroscopy, and 13C NMR spectroscopy. The biological activity of these prepared compounds was preliminarily evaluated against certain types of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli). The results showed a high antibacterial effect towards both types of bacteria at high concentrations.
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Abdulwahid et al. (2025) studied this question.
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