This review outlines the functions and applications of fibroblast growth factor-derived peptides, suggesting their potential in tissue repair and metabolic regulation.
Fibroblast growth factors (FGFs) play a crucial role in various biological processes, including tissue development, metabolic regulation, and injury repair. Previous studies have shown that certain peptides can exhibit similar biological functions to FGFs, whether they are fragments extracted from natural FGF molecules or derived peptides designed based on the structural characteristics of FGFs and their receptor molecules. These FGF-derived peptides have shown significant application potential in fields including tissue repair and regeneration, cancer therapy, metabolic regulation, neural recovery, and biological delivery. This article reviews the sources, bioactive functions, molecular mechanisms, and application prospects of FGF-derived peptides, aiming to provide new research ideas for subsequent structural optimization, drug delivery system development, and clinical translation of these peptides.
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Cao et al. (2025) studied this question.
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