September 27, 2025Journal of Clinical MedicineOpen Access

Evaluation of [11C]-Methionine Positron Emission Tomography and Cerebral Blood Volume Imaging in the Diagnosis of Non-Contrast-Enhanced Gliomas

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Methionine and rCBV significantly correlated, enhancing diagnostic accuracy in gliomas.
Receiver operating characteristic analyses showed rCBV trended towards higher AUC values in glioblastoma versus astrocytoma.
rCBV differentiation of glioma subtypes was reliable but varied, being notably useful for astrocytoma.
Identifying these differences highlights rCBV as a practical tool for assessing non-contrast-enhanced gliomas.

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Retrospective analysis showed accurate differentiation of glioma subtypes using methionine PET and cerebral blood volume imaging.

Imai et al. (2025) studied this question.

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