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September 27, 2025Intensive Care MedicineOpen Access

Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study

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Observational cohort study examines outcomes of acute respiratory distress syndrome in cancer patients, suggesting ECMO may not improve mortality.

Patients with cancer and severe ARDS experience high 90-day mortality, with rates reaching 82.2% in this cohort.
Out of 715 patients, ICU and hospital mortality rates stood at 55.3% and 70.9% respectively, indicating substantial risks.
Multinational observational cohort study across 13 countries assessed clinical characteristics and outcomes in patients with ARDS.
These findings call for careful evaluation of ECMO guidelines and the need for nuanced discussions on goals of care in this population.

Schellongowski et al. (2025) studied this question.

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Observational cohort study examines outcomes of acute respiratory distress syndrome in cancer patients, suggesting ECMO may not improve mortality.