This method reveals a novel desaturative cyclization of tertiary alkylamines and aldehydes, suggesting potential for efficient synthesis of pyrido[3,2-c]coumarins.
Utilizing the auto-oxidation of tertiary alkylamines and aromatic aldehydes, an unprecedented desaturative cyclization with 4-aminocoumarins has been achieved without the need for additional catalysts or reagents. This vicinal C(sp3)−H cyclization...
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Bai et al. (2025) studied this question.
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