Key result
AAOCA is not associated with increased mortality or MACE compared to normal coronary anatomy.
Why the study?
Does anomalous aortic origin of a coronary artery (AAOCA) increase the risk of mortality and major adverse cardiac events in adults compared to normal coronary anatomy?
Cohort (n=173)
No
Does anomalous aortic origin of a coronary artery (AAOCA) increase the risk of mortality and major adverse cardiac events in adults compared to normal coronary anatomy?
p-value: p=0.321 for mortality, 0.392 for MACE
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In adults with AAOCA, the anomaly itself does not increase the risk of mortality or MACE compared to normal coronary anatomy; adverse events are primarily driven by concomitant obstructive coronary atherosclerotic disease.
Gentile et al. (2025) conducted a cohort in Anomalous aortic origin of a coronary artery (AAOCA) (n=173). Anomalous aortic origin of a coronary artery (AAOCA) vs. Matched controls with normal coronary artery anatomy was evaluated on All-cause mortality and major adverse cardiac events (nonfatal acute coronary syndromes, revascularization procedures, and heart failure hospitalization) (p=0.321 for mortality, 0.392 for MACE). Anomalous aortic origin of a coronary artery was not associated with increased mortality (P=0.321) or major adverse cardiac events (P=0.392) compared to matched controls with normal anatomy.
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