What type of study is this?

This is a In Vitro Study study (also classified as: Animal Study).

September 27, 2025Brain

Inhibition of GluN2B-containing N-methyl-d-aspartate receptors by radiprodil

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Authors

TBTue G. BankeAarhus University MRMichael C. ReganCold Spring Harbor Laboratory RPRiley E. PerszykEmory University

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Implication

This research evaluates radiprodil's effectiveness in blocking GluN2B-containing NMDA receptors, suggesting its potential therapeutic roles in neurological conditions.

Key Points

Radiprodil effectively inhibits GluN2B-containing NMDA receptors, supporting its potential in treating neurological disorders.
Inhibition was shown to be over 80% effective against human GRIN1 and GRIN2B missense variants tested in vitro.
Radiprodil delayed seizures in vivo compared to a vehicle group, suggesting possible therapeutic benefits in epilepsy.
Structural analysis revealed specific binding interactions of radiprodil with GluN2B, guiding future drug development efforts.

Cite This Study

Banke et al. (2025) studied this question.

synapsesocial.com/papers/68d7b3edeebfec0fc52372b8 https://doi.org/10.1093/brain/awaf355

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Implication

This research evaluates radiprodil's effectiveness in blocking GluN2B-containing NMDA receptors, suggesting its potential therapeutic roles in neurological conditions.

Inhibition of GluN2B-containing N-methyl-d-aspartate receptors by radiprodil

Discussion

Member takes

Implication

Key Points

Cite This Study

Inhibition of GluN2B-containing N-methyl-d-aspartate receptors by radiprodil

Discussion

Member takes

Implication

Key Points

Cite This Study

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