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September 27, 2025World Journal of Hepatology

Explant-based prognostic models for hepatocellular carcinoma recurrence after liver transplantation: A systematic review and meta-analysis

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Authors

IBInácio de BarrosMFMatheus Vanzin FernandesSVSantiago Rodríguez Villafuerte

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Overview

Systematic review assessed prognostic models for HCC recurrence after liver transplantation, indicating limitations in sensitivity.

Key Points

  • The overall recurrence rate for hepatocellular carcinoma after liver transplantation was found to be 7%, indicating ongoing risk post-surgery.
  • For the RETREAT, Decaens, and PCRS models, sensitivity and specificity varied, highlighting the challenging nature of accurately predicting outcomes.
  • All included studies were retrospective, encompassing nine cohorts across North America, Europe, and Asia, stressing the need for diverse validation.
  • Despite multiple models being assessed, no single approach showed clear superiority, suggesting further development is needed.

Cite This Study

Barros et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc52376dbhttps://doi.org/10.4254/wjh.v17.i9.111126
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