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September 27, 2025Human Brain MappingOpen Access

Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting‐State fMRI Study Using Co‐Activation Pattern Analysis

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Authors

XWXingsong WangYZYao ZhangPWPing Wang

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Overview

Analysis of brain network dynamics shows altered connectivity patterns in schizophrenia patients, suggesting implications for treatment.

Key Points

  • Patients with predominant negative symptoms displayed excessive state transitions and reduced dwell time in brain networks.
  • Overall schizophrenia patients showed altered temporal characteristics compared to healthy controls, including changes in sensorimotor dominance.
  • Utilizing co-activation pattern analysis of rs-fMRI data, the study reveals critical dynamics often overlooked by static connectivity analyses.
  • Network alterations correlated with symptom severity, highlighting potential neuroimaging markers for clinical assessment in schizophrenia.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc523772dhttps://doi.org/10.1002/hbm.70369
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