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September 27, 2025Frontiers in Medical EngineeringOpen Access

The role of micro-CT in breast cancer management: a systematic review on the clinical applications of micro-CT in breast cancer and a diagnostic accuracy meta-analysis on intraoperative margin assessment

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Authors

SYSeyed Mostafa Meshkati YazdMVMahtab VasighΑPΑndreas S. Papazoglou

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Overview

Systematic review assesses micro-CT's role in margin assessment during breast-conserving surgeries, revealing its diagnostic accuracy.

Key Points

  • Micro-CT imaging has a sensitivity of 0.63 and specificity of 0.78 for assessing intraoperative margins of breast cancer specimens.
  • The study analyzed eight eligible studies, with 988 specimens scanned using micro-CT for intraoperative assessments.
  • Micro-CT provides high-resolution 3D images in 4 to 30 minutes, aiding surgeons in evaluating margin status during operations.
  • Further clinical trials are needed to confirm the long-term impacts of micro-CT IMA on re-excision and recurrence rates.

Cite This Study

Yazd et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc523779bhttps://doi.org/10.3389/fmede.2025.1571528
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhancing precision in breast conserving surgery: introduction to emerging imaging technologies2026
  2. 2Abstract PS2-05-28: High-resolution specimen PET-CT imaging for intraoperative margin assessment in early-stage breast cancer: the multicenter BrIMA study2026
  3. 3191P Automated contouring (AC) of cardiac substructures using AI-based algorithms on whole breast radiation therapy (RT) CT-scans for NRG oncology RTOG 1005 (R1005)2026
  4. 4MRI-Guided Tumor Margin Assessment in Breast Cancer Surgery: Implications for Plastic and Cosmetic Breast Reconstruction2023
  5. 5A review on the use of radionuclide imaging techniques to detect margin positivity in intraoperative specimens during breast-conserving surgery2025