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September 27, 2025Frontiers in ImmunologyOpen Access

Systemic dysregulation of the gut microenvironment plays a pivotal role in the onset and progression of inflammatory bowel disease

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Authors

RKRuilong KouYGYonggang GuoZQZhiwei Qin

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Overview

This review explores gut dysbiosis and immune activation in inflammatory bowel disease, suggesting an integrated approach for restoration.

Key Points

  • Gut dysbiosis decreases beneficial microbiota and increases pathogenic bacteria, disrupting the gut microbiome.
  • The imbalance in metabolites leads to intestinal barrier dysfunction, compromising gut integrity and allowing harmful substances through.
  • Activating innate and adaptive immune responses initiates an inflammatory cycle, contributing to chronic IBD.
  • A comprehensive intervention strategy could reshape treatments by restoring intestinal homeostasis and disrupting the pathological cycle.

Cite This Study

Kou et al. (2025) studied this question.

synapsesocial.com/papers/68d7be5eeebfec0fc52377b3https://doi.org/10.3389/fimmu.2025.1661386
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Microbiome in the Development and Treatment of Inflammatory Bowel Disease2026
  2. 2Current Perspectives on the Inflammatory Bowel Disease Pathogenesis of Microbiota and the Gut-Brain Axis, and Emerging Therapeutics2026 · 4 citations
  3. 3Gut microbial metabolites in inflammatory bowel disease: immunological mechanisms regulating Treg/Th17 balance and therapeutic potential2026 · 11 citations
  4. 4Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease2024 · 1 citations
  5. 5Exploring the Gut Microbiome’s Role in Inflammatory Bowel Disease: Insights and Interventions2024 · 35 citations