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September 27, 2025Frontiers in Cell and Developmental BiologyOpen Access

Systematic characterization of cross-source miRNA biomarkers in prostate cancer with computational-experimental integrated analysis

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Authors

HLHuimin LuLWLI WenjinZHZhongxin Huang

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Overview

This analysis reveals key miRNAs and their networks in prostate cancer, suggesting therapeutic targets.

Key Points

  • The study identified 948 target genes linked to downregulated miRNAs in prostate cancer, with implications for diagnosis.
  • Key findings include the observation that miR-136-3p was significantly reduced in both serum and tissue samples, indicating a potential biomarker.
  • Utilizing comprehensive datasets, the research constructed miRNA–mRNA networks through differential expression and pathway analysis.
  • This integrated approach highlights the relevance of specific miRNAs in prostate cancer, paving the way for future therapeutic strategies.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/68d7be62eebfec0fc5237841https://doi.org/10.3389/fcell.2025.1605297
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