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September 27, 2025Frontiers in OncologyOpen Access

Case Report: Androgen receptor-positive, locoregionally advanced breast cancer in a transgender man and an update on breast cancer management in a gender-diverse patient population

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Authors

YRYastira RamdasTRTrenton ReinickeCSC. Schnurr

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Overview

Case report reveals a complete metabolic response after personalized treatment in a transgender man, highlighting the role of androgen receptors.

Key Points

  • A 70-year-old transgender man with locoregionally advanced breast cancer achieved a complete metabolic response after treatment.
  • Post-treatment analysis showed a near complete pathologic response in the breast, with three sentinel lymph nodes achieving a complete response.
  • Shared decision-making guided the treatment approach, incorporating neoadjuvant HER2-directed chemotherapy and surgical interventions.
  • This case stresses the need for personalized management strategies in gender-diverse patient populations with breast cancer.

Cite This Study

Ramdas et al. (2025) studied this question.

synapsesocial.com/papers/68d7be62eebfec0fc5237991https://doi.org/10.3389/fonc.2025.1654048
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