September 27, 2025Open Access

Beyond pulling: microtubule pushing forces contribute to robust spindle orientation in regular and irregular cell shapes

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Authors

AYAlikhan YeltokovUniversity of Rochester TFTara M. FineganUniversity of Missouri AFAlexander G. FletcherNorthern Illinois University

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Implication

Computational model demonstrates how microtubule and dynein forces affect spindle dynamics in diverse cell types, indicating crucial roles of pushing forces.

Key Points

Spindle orientation relies primarily on pulling forces but pushing forces are vital for preventing stalling.
The model accurately reflects spindle behavior in Drosophila and C. elegans, showing significant results across cell geometries.
Irregular cell shapes like those in zebrafish highlight the importance of force distribution at junctions for spindle positioning.
This model offers insights into the interplay of geometry and physical forces in both canonical and non-canonical cell divisions.

Cite This Study

Yeltokov et al. (2025) studied this question.

synapsesocial.com/papers/68d7be62eebfec0fc5237aaf https://doi.org/10.1101/2025.09.22.677921

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Implication

Computational model demonstrates how microtubule and dynein forces affect spindle dynamics in diverse cell types, indicating crucial roles of pushing forces.

Beyond pulling: microtubule pushing forces contribute to robust spindle orientation in regular and irregular cell shapes

Discussion

Member takes

Implication

Key Points

Cite This Study

Beyond pulling: microtubule pushing forces contribute to robust spindle orientation in regular and irregular cell shapes

Discussion

Member takes

Implication

Key Points

Cite This Study

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