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September 27, 2025Open Access

Iron Overload and Endocrine Dysfunction in Adults with Transfusion-Dependent Beta-Thalassemia and Growth Retardation: A Correlational Study

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Authors

MHMuhammad HammadSFSadaf FardoosKKhadija

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Overview

Correlational study reveals iron overload impacts endocrine dysfunction and growth in adults with TDT, highlighting critical diagnostic markers.

Key Points

  • Significant negative correlations exist between serum ferritin and thyroid hormones and growth factors.
  • Patients with high ferritin levels show elevated prevalence of low IGF-1, complicating growth maintenance.
  • MRI T2* values positively correlate with thyroid function and IGF-1, suggesting its diagnostic importance.
  • Iron overload and pancreatic burden are closely linked with endocrine dysfunctions in adult TDT patients.

Cite This Study

Hammad et al. (2025) studied this question.

synapsesocial.com/papers/68d7be66eebfec0fc5237bedhttps://doi.org/10.20944/preprints202509.1900.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron Overload and Endocrine Dysfunction in Adults with Transfusion-Dependent Beta-Thalassemia and Growth Retardation: A Correlational Study2026 · 1 citations
  2. 2Endocrine dysfunction in transfusion-dependent and non-transfusion-dependent beta-thalassemia: a systematic review and meta-analysis2026
  3. 3Bone Mineral Density and Endocrinopathies in Adults with Transfusion-Dependent Beta-Thalassemia Major Patients from Oman2024
  4. 4Magnetic Resonance Imaging Versus Serum Iron Status as Diagnostic Tools for Pituitary Iron Overload in Children with Beta Thalassemia2021
  5. 5Endocrinopathies in adult Egyptian thalassemia patients, a cross-section study, single-center experience2025