September 27, 2025Open Access

Hepatic adverse effects of valproic acid: what action to take?

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Discussion

Retrospective study assessed hepatic cytolysis cases linked to valproic acid, suggesting careful monitoring.

Management of valproic acid-related hepatic cytolysis varies by severity, with fatal outcomes in some cases.
Eight cases of hepatic cytolysis were identified, including one fatal case and six benign cases.
Pharmacovigilance methods highlighted a need for dose reduction or cessation based on transaminase levels.
Monitoring plasma valproic acid levels is essential for adjusting treatment decisions and ensuring patient safety.

Bouaziz et al. (2025) studied this question.

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