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September 27, 2025Open Access

Slow trajectories generate divergent cell fates following antibiotic stress

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Authors

ELEthan LevienJCJoão Pedro Teuber CarvalhoLHLinh Huynh

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Overview

Experiments reveal slow-growing phenotypes in microbes under antibiotic stress, suggesting that initial resource allocation predicts cell fate.

Key Points

  • Divergence in cell fates occurs due to slow growth after antibiotic stress, with key implications for survival.
  • Initial resource allocation significantly influences the emergence of slow-growing phenotypes, impacting cell survival.
  • A new model connects gene expression and growth dynamics, predicting distinct phenotypes and their survival trajectories.
  • These findings challenge traditional views on bistability, highlighting slow growth as a stabilizing mechanism for cellular states.

Cite This Study

Levien et al. (2025) studied this question.

synapsesocial.com/papers/68d7be6ceebfec0fc523816ahttps://doi.org/10.1101/2025.09.25.678360
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