Application of Fe₃O₄@SiO₂@APIDSO₃H as a Novel Magnetic Nanocatalyst in Domino‐Knoevenagel–Phospha‐Michael Reaction

This research describes a synthesis method using Fe 3 O 4 @SiO 2 @APIDSO 3 H as a magnetic nanocatalyst for preparing α‐substituted phosphonates by domino‐Knoevenagel–phospha‐Michael reaction. The reaction involves 1,3‐dicarbonyl compounds (dimedone and 1,3‐dimethyl barbituric acid) reacting with different aromatic aldehydes and triethyl phosphite. The Fe 3 O 4 @SiO 2 @APIDSO 3 H catalyst was previously prepared and characterized. The synthesized products were identified using 1 H‐NMR, 13 C‐NMR, 31 P‐NMR, FT‐IR spectroscopy, and CHNS analysis. The resulting compounds possess reactive functional groups in their structure, making them suitable as building blocks for further chemical modifications in medicinal and biochemical applications. This approach also offers advantages like catalyst recovery and reusability, short reaction times, and simplified workup procedures.