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September 28, 2025Open Access

Electric Field-Induced Destabilization and Surface Modulation of Aβ42 Fibrils in Molecular Simulations: Theoretical Implications for DC Stimulation in Alzheimer's Disease

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Authors

FTFran Bačić ToplekUniversity of MilanNMNatale Vincenzo MaioranaUniversity of MilanMGMatteo GuidettiUniversity of Milan

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Implication

Molecular dynamics simulations reveal electric field impact on fibril destabilization and modulation in amyloid pathology, indicating potential therapy routes.

Key Points

  • Electric fields may destabilize Aβ42 fibrils, compromising their structure and reducing stability.
  • Molecular simulations indicated that electric fields alter the dynamics of the fibril's N-terminal regions and surface properties.
  • Structural restraint conditions in simulations demonstrated varying effects on the fibril's conformational stability.
  • Findings suggest that stronger electric fields might influence amyloid aggregation, warranting further experimental validation.

Cite This Study

Toplek et al. (2025) studied this question.

synapsesocial.com/papers/68d8f313d88e2624dc4c5572https://doi.org/10.1101/2025.09.24.678267
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