B – 150 Performance Validity Failure Rates in a Clinical Sample of Deep Brain Stimulation Candidates with Parkinson’s Disease

Objective Patients with Parkinson’s disease (PD) who are candidates for deep brain stimulation (DBS) surgery complete neuropsychological evaluation as part of standard pre-surgical workup. To our knowledge, one study has investigated PVT performance in DBS candidates with PD (n=20), who tend to be highly motivated to perform well and are at higher risk for cognitive decline (Rossetti et al., 2018). Method The sample was 53 patients with PD (3 with PD dementia; PDD) referred for comprehensive pre-DBS neuropsychological evaluation. Mean age was 69.19 (SD=6.49, range=47-79), mean education of 15.32 years (SD=3.13, range=8-20), 79.2% male, and 98.1% White. PVTs examined included CVLT-3 Forced Choice Recognition (CVLT-3-FCR), ACS Word Choice Test Accuracy and Time to completion (WCT-A, WCT-T), Reliable Digit Span (RDS), BVMT-R Recognition Discriminability (BVMT-R-RD), and/or Wisconsin Card Sorting Test Failure to Maintain Set (WCST-FMS). Cutoffs for PVT failure were CVLT-3-FCR score < 15, WCT-A ≤45, WCT-T ≤171 seconds, RDS ≤6, BVMT-R-RD ≤4, and WCST-FMS ≥3. Results Failure rates were WCST-FMS 5.4% (n=2 PD), CVLT-3-FCR 5.7% (n=2 PD, 1 PDD), RDS 11.9% (n=3 PD, 2 PDD), WCT-A and WCT-T 14.8% (n=4 PD), and BVMT-R-RD 25.5% (n=12 PD, 1 PDD). Failing a PVT was not related to age or mood. BVMT-R-RD was associated with fewer years of education. Conclusion Pre-DBS patients with PD rarely fail any given PVT except for BVMT-R-RD, suggesting it may be overly sensitive. Further research examining the sensitivity and specificity of stand-alone and embedded PVTs in patients with PD, including those being considered for neurosurgery and those with PDD, will be important.