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September 28, 2025Analytical ChemistryOpen Access

A Flexible End-to-End Automated Sample Preparation Workflow Enables Standardized and Scalable Bottom-up Proteomics

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The automated sample preparation platform achieved high reproducibility and longitudinal consistency in workflows, enhancing accuracy.
Compared to manual processes, the new workflow offers significant improvements in time efficiency and throughput for sample preparation.
This platform enables drug development by allowing precise protein quantification and proteome profiling for targeted degradation studies.
The integration of automation facilitates rapid adaptation to new developments, driving advancements in clinical assays and research.

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Automated workflows improve reproducibility and efficiency in bottom-up proteomics, suggesting scalability for clinical studies.

Schär et al. (2025) studied this question.

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