Background Malnutrition, inflammation, and atherosclerosis interact in further kidney disease progression. Despite continuous improvement in renal clearance techniques, indicators of morbidity and mortality are still high for people with end-stage renal disease. The current work aims to study the role of hematological parameters as markers of inflammation and malnutrition in dialysis-dependent chronic kidney disease patients. Patients and method The study included 51 patients on chronic hemodialysis and 10 healthy controls. Malnutrition-Inflammation Score (MIS), prognostic nutritional index (PNI), neutrophil/lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and platelet/lymphocyte ratio (PLR) were calculated. Results There was a statistically significant difference between the studied groups regarding PNI and MIS scores ( P =0.016 for each) and PLR and regarding SII ( P <0.001, for each). There was a statistically highly significant difference between SII and each of NLR, PLR, neutrophils, hemoglobin, and platelets ( P <0.001, for each). Also, there was a statistically significant difference between SII and each of the total white blood cells (WBCs) and HbA1c ( P =0.028 and 0.001, respectively). There was a statistically significant difference between PNI and each of total WBCs, platelets, albumin, and erythrocyte sedimentation rate ( P =0.003, 0.008, 0.001, 0.021, respectively). Also, there was a statistically highly significant difference between PNI and lymphocytes ( P <0.001). There was a statistically highly significant difference between NLR and each of SII and neutrophils ( P <0.001, for each). Also, there was a statistically significant difference between NLR and each of the total WBCs, PLR, and erythrocyte sedimentation rate ( P =0.001, 0.04, 0.001, respectively). Conclusion Disturbances in hematological-based indices such as NLR, PLR, MIS, and SII in end-stage renal disease patients can affect the outcome of chronic hemodialysis patients.
Abdelmoneem et al. (Tue,) studied this question.