Key result
Major depressive disorder, present in 24.1% of hemodialysis patients, was associated with significantly higher IL-6 levels and correlated with fatigue, quality of life, and albumin levels.
Cross-Sectional (n=195)
In patients undergoing hemodialysis, serum levels of albumin and IL-6 are significantly associated with the expression of emotional symptoms such as depression and fatigue.
Supports depression screening in hemodialysis; leaves open whether IL-6 is causal or a treatment target.
OBJECTIVE: Hemodialysis has an adverse impact on the immunological, nutritional, and emotional status of patients. The biochemical markers of inflammation and nutrition were studied as well as the relationship of these factors to emotional symptoms. METHOD: One hundred and ninety-five patients undergoing hemodialysis were enrolled. The mean age was 58.5 years. Emotional symptoms were assessed using the Mini International Neuropsychiatric Interview, Hospital Anxiety and Depression Scale, Chalder Fatigue Scale, and Short-form Health-related Quality of Life. Venus blood was collected for laboratory assessment of serum hemoglobin, albumin, ferritin, C-reactive protein, interleukin (IL) 1beta), IL-6, and tumor necrosis factor alpha. RESULTS: Among the 195 subjects (92 men and 103 women), 47 (24.1%) fulfilled the criteria for a major depressive disorder (MDD). The IL-6 level in patients with a MDD was significantly higher than in the patients without a MDD. Significant correlation was observed among the following factors: IL-6, fatigue, and quality of life for both physical and mental components. The albumin levels showed a significant correlation with the IL-6 and depression scores. CONCLUSIONS: These results show that the serum levels of albumin and IL-6 might be laboratory markers associated with the expression of emotional symptoms in patients undergoing hemodialysis. Prospective studies are needed to determine the causal relationships among these variables.
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Wang et al. (2012) conducted a cross-sectional in Chronic Renal Failure Undergoing Hemodialysis (n=195). Major depressive disorder vs. Patients without major depressive disorder was evaluated on IL-6 levels and correlation with emotional symptoms. Major depressive disorder, present in 24.1% of hemodialysis patients, was associated with significantly higher IL-6 levels and correlated with fatigue, quality of life, and albumin levels.
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