Intracameral and Intravitreal Chemotherapy Combined With Intra-arterial Chemotherapy for a Recurrent Retinoblastoma With Anterior Chamber and Vitreous Seeding

The authors describe a Chinese boy presenting with recurrent retinoblastoma in combination with anterior chamber and vitreous seeding. After two cycles of intra-arterial chemotherapy combined with intracameral and intravitreal melphalan injections, the retinal tumor regressed. The seeds in the anterior chamber and vitreous body were invisible. After 12 months of follow-up, extraocular metastasis was not demonstrated and the retinal tumor was stable. The visual acuity of this patient remained 20/30.