Palladium‐Catalyzed Four‐Component Radical Carbonylation Reaction for the Construction of Benzofuranamide Derivativesitle

A novel palladium‐catalyzed four‐component radical tandem cyclization‐carbonylation of 1,6‐enynes with aniline, carbon monoxide, and ethyl difluoroiodoacetate is reported. This approach facilitates a multicomponent reaction involving tandem 1,2‐double bond migration, thereby allowing the efficient synthesis of alkylamide‐substituted benzofuranamide derivatives. The proposed strategy demonstrates a broad substrate scope, high efficiency in bond migratory‐rearrangement, and controllable selectivity in the order of component addition.