Anticancer potential of ethanolic sidr leaf extracts against MCF-7 breast cancer cells: phytochemical, nutritional, and antimicrobial profile comparisons of different plant parts

Background Traditional medicine has long utilized natural plants to treat diseases and promote overall health. They have contributed significantly to the creation of modern medications. To supplement existing information, therefore, this current investigation aimed to understand the potential therapeutic properties of the sidr plant against triple negative breast cancer (TNBC) on MCF-7 breast cell line by conducting phytochemical, nutritional, and antimicrobial profile comparisons of different plant parts. Methods Phytochemical analyses involved soluble sugar composition and oxidation profile, whereas nutritional analysis involved the proximate chemical analysis. Additionally, antimicrobial analyses involved six kings of food-borne bacterial strains. Results According to the study, leaves possessed the highest amounts of protein (12.44%) and ash (8.17%), as well as the highest amounts of ascorbic acid and total chlorophyll. On the other hand, pulps exhibited the highest flavonoid concentration in their ethanolic extract and had higher sugar contents. Furthermore, at a dosage of 100 µg/mL, the ethanolic extract of leaves showed potent antimicrobial action and suppressed over 50% of MCF-7 breast cancer cell survival. Conclusions Bioactive components, antioxidant, antimicrobial and nutritional elements of sidr plant appears a promising medicinal candidate to fight breast cancer cells.