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This is a In Vitro Study study (also classified as: Experimental Study).

September 28, 2025GelsOpen Access

Development and Evaluation of Nystatin-Loaded Novasomal Gel for the Treatment of Candida albicans Infection: In Vitro Microbiological and Skin Compatibility Study

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The nystatin-loaded novasomal gel demonstrated a significant antifungal effect against Candida albicans, achieving a 23 mm inhibition zone.
Drug release over 12 hours was sustained, with measurable entrapment efficiencies reaching 80% for the most effective formulation.
In vitro characterization confirmed that the novasomal gel had stable pH, viscosity, and optimal particle size for dermal use.
Skin irritation tests on rats indicated the gel was non-irritant, supporting its potential for clinical application.

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In vitro study shows nystatin-loaded novasomal gel improves antifungal efficacy and skin compatibility.

Mustafa et al. (2025) studied this question.

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