Cervical cancer screening in patients at a tertiary care centre with Pap smear and HPV DNA testing
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Key Points
HPV DNA testing demonstrates superior accuracy with 100% sensitivity and over 95% specificity, making it an effective screening tool.
Pap smear shows high specificity at ~93.9% and a strong negative predictive value at 99.1%, but has a low positive predictive value of 18%-25%.
Cervical cancer remains a leading cause of cancer mortality in women, particularly in India where new cases account for a significant portion globally.
The findings highlight the necessity of confirmatory tests due to the high false-positive rate associated with Pap smears.
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Implication
Cross sectional study assesses cervical cancer screening effectiveness in women using Pap smear and HPV DNA testing, indicating HPV's superior accuracy.