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September 28, 2025Open Access

Comparing the predictive value of plasma p-tau217 and CSF biomarkers (p-tau181, Aβ42) using amyloid positron emission tomography in Alzheimer's continuum

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Authors

MAMohammad Hossein AzaraeinEZElham ZarrazvandFHFatemeh Heydari

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Overview

Cross-sectional analysis reveals plasma ptau217's superior predictive accuracy for Alzheimer's disease, suggesting it may enhance diagnostic methods.

Key Points

  • Plasma ptau217 demonstrated the strongest correlation with amyloid-β deposition and clinical scores, outperforming other biomarkers.
  • Adjusted R² values were 0.53 for ADAS and 0.51 for CDR, indicating a strong relationship with clinical assessments.
  • Cross-sectional analysis was conducted on individuals with mild cognitive impairment to evaluate various biomarkers.
  • This finding supports plasma ptau217 as a cost-effective, non-invasive alternative for early Alzheimer's diagnosis.

Cite This Study

Azaraein et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0141e1c178a14f5ee3https://doi.org/10.21203/rs.3.rs-7327653/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Baseline plasma p-tau217/Aβ42 as a sensitive marker for the severity of Alzheimer’s disease continuum2026 · 1 citations
  2. 2From Cerebrospinal Fluid to Blood Draw: Plasma p-Tau217 as a Non-Invasive Biomarker for Alzheimer’s Disease: A Fagan Nomogram-Based Meta-Analytic Study2026
  3. 3Plasma p-tau217, p-tau181 and Aβ42/40 for Alzheimer’s disease diagnosis: ROC accuracy and 18F-florbetapir amyloid PET-CT concordance2026
  4. 4Validation of plasma core biomarkers of Alzheimer's disease: A multicenter study in usual practice conditions2026
  5. 5Plasma p-tau217, p-tau181, and Aβ42 predict amyloid PET positivity in cognitively unimpaired adults2026 · 3 citations