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This is a Experimental Study study.

Biomaterial-Driven Nanodrug Formulation for Enhanced Bone Regeneration in Osteoporosis

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Nanodrug delivery improves bone density and quality in ovariectomized rats, suggesting a novel osteoporosis treatment.

RX-CD-SNEDDs improved bone mineral density, trabecular microarchitecture, and bone quality in ovariectomized rats.
The nanoformulation exhibited ∼2-fold higher in vitro release and ∼3.91-fold higher cellular uptake than free-RX-CD.
Analysis utilized Box–Behnken design for optimization, leading to a stable nanosystem under 200 nm in size.
Nanoscale properties of RX-CD-SNEDDs show great potential for treating postmenopausal osteoporosis effectively.

Chauhan et al. (2025) studied this question.

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