The rise and fall of blood pressure and cognitive function: implications for sex differences in brain health

Kevin S. Heffernan; R. Townsend

doi:10.1093/ajh/hpaf197

September 26, 2025American Journal of Hypertension

The rise and fall of blood pressure and cognitive function: implications for sex differences in brain health

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Key Points

Increased variability in blood pressure is linked to cognitive decline, particularly in older adults.
Findings indicate potential gender disparities, with women experiencing greater cognitive impact from blood pressure changes.
Assessment involved measuring blood pressure fluctuations and cognitive assessments across diverse populations.
These results underscore the need for targeted interventions in managing blood pressure based on sex differences.

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Implication

Observational analysis finds that variations in blood pressure impact cognitive function in adults, highlighting sex differences.

Abstract

Journal Article Accepted manuscript The rise and fall of blood pressure and cognitive function: implications for sex differences in brain health Get access Kevin S Heffernan, Kevin S Heffernan Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA Corresponding Author: Kevin S. Heffernan, PhD, Associate Professor of Biobehavioral Sciences, Director of the Applied Neurovascular Physiology Lab, Teachers College, Columbia University, New York, NY 10027, [email protected] Search for other works by this author on: Oxford Academic PubMed Google Scholar Raymond R Townsend Raymond R Townsend Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Hypertension, hpaf197, https://doi.org/10.1093/ajh/hpaf197 Published: 26 September 2025 Article history Received: 13 September 2025 Revision received: 18 September 2025 Accepted: 22 September 2025 Published: 26 September 2025

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Heffernan et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0641e1c178a14f61fb https://doi.org/10.1093/ajh/hpaf197

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The rise and fall of blood pressure and cognitive function: implications for sex differences in brain health

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The rise and fall of blood pressure and cognitive function: implications for sex differences in brain health

Key Points

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Implication

Abstract

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Cite This Study

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