This method demonstrates efficient c(sp3)-h oxidation in quinolines, using air as an oxidant, highlighting its potential for post-synthetic modifications.
Visible light enabled C(sp3)-H oxidation of 8-alkylquinolines has been accomplished utilizing [Mes-Acr-Me]BF4 under air. The reaction offers an effective synthetic approach to direct access C8-carbonyl quinolines bearing aldehydes, ketones and esters groups and allows other important functional handle through Post-synthetic modification. The site-selective C(sp3)-H oxidation, use of air as oxidant, substrate scope and post-synthetic potential are the salient practical features.
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Mandal et al. (2025) studied this question.
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