September 28, 2025HLA

The Novel HLA‐DPB1*1799:01 Allele Identified by Next‐Generation Sequencing in Two Members of an Indian Family

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The novel hla-dpb1*1799:01 allele differs from the known variant by a single amino acid change.
This change occurs in exon 3 at codon 148, highlighting the specificity of the genetic variation.
Next-generation sequencing enabled the precise identification of this allele in family members.
Understanding this allele's role could be crucial for studying genetic diversity in the Indian population.

Implication

Novel allele hla-dpb1*1799:01 reveals a non-synonymous change in exon 3, suggesting genetic diversity.

HLA‐DPB1*1799:01 differs from HLA‐DPB1*05:01:01:01 by a single non‐synonymous change in exon 3, changing codon 148 from AAT → AAA.

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Agarwal et al. (2025) studied this question.

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Novel allele hla-dpb1*1799:01 reveals a non-synonymous change in exon 3, suggesting genetic diversity.

HLA‐DPB1*1799:01 differs from HLA‐DPB1*05:01:01:01 by a single non‐synonymous change in exon 3, changing codon 148 from AAT → AAA.