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September 28, 2025Journal of Clinical MedicineOpen Access

Structural and Functional Outcomes in Rheumatoid Arthritis After 10-Year Therapy with Disease-Modifying Antirheumatic Drugs Under Tight Control: Evidence from Real-World Cohort Data

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Authors

SMShunsuke MoriOkayama Shoka UniversityAOAkitomo OkadaKyushu Institute of Information SciencesTSToshimasa ShimizuNagasaki University

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Implication

Observational analysis showed structural and functional remission in rheumatoid arthritis patients, indicating the effectiveness of DMARD therapy.

Key Points

  • 68.1% of patients achieved clinical remission after 10 years of treatment with DMARDs.
  • Among 204 rheumatoid arthritis patients, structural remission occurred in 73% and functional remission in 81.4%.
  • Real-world cohort data revealed important predictors of remission after long-term DMARD therapy.
  • JSN score was found to be a significant predictor for both structural and functional remission outcomes.

Cite This Study

Mori et al. (2025) studied this question.

synapsesocial.com/papers/68d90a0641e1c178a14f6412https://doi.org/10.3390/jcm14196832
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Measuring function in rheumatoid arthritis: Identifying reversible and irreversible components2006 · 277 citations
  2. 2Longterm Effect of Delaying Combination Therapy with Tumor Necrosis Factor Inhibitor in Patients with Aggressive Early Rheumatoid Arthritis: 10-year Efficacy and Safety of Adalimumab from the Randomized Controlled PREMIER Trial with Open-label Extension2013 · 54 citations
  3. 3Ten-year radiographic and functional outcomes in rheumatoid arthritis patients in remission compared to patients in low disease activity2023 · 9 citations
  4. 4Have radiographic progression rates in early rheumatoid arthritis changed? A systematic review and meta-analysis of long-term cohorts2016 · 29 citations