This method demonstrates hydrogen atom transfer to generate homoallylic amines, suggesting new pathways for alkene synthesis.
Herein, we present an organophotoredox-catalyzed nitrogen-centered radical-triggered allylation reaction that enables the synthesis of trisubstituted alkenes from MBH adducts and N-trifluoroethylhydroxylamine reagents or hydroxamides via a hydrogen atom transfer (HAT) strategy. When N-trifluoroethylhydroxylamine reagents were employed as radical precursors, various homoallylic α-trifluoromethylamines were generated through 1,2-HAT of the in situ-generated N-trifluoroethyl radicals. Moreover, a series of hydroxamides (1,5-HAT reagents) could be tolerated by this catalytic system, affording the corresponding alkyl amides with excellent yields.
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Wang et al. (2025) studied this question.
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