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This is a Experimental Study study.

September 28, 2025

Mechanical stimulation of extracellular vesicles secreted by bone marrow mesenchymal stem cells promotes osteoblast proliferation and differentiation by activating the Wnt/β - catenin signaling pathway.

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Experimental analysis shows MS-Exo boosts osteoblast function in GIOP, suggesting new treatment avenues.

MS-Exo significantly reversed dexamethasone's suppression of osteoblast proliferation and differentiation, promoting bone health.
Cell proliferation assays showed a remarkable increase with MS-Exo, elevating osteogenic marker gene expression.
Transcriptomic analysis indicated strong activation of the Wnt/β-catenin signaling pathway in MS-Exo treated cells.
Findings imply that mechanical stimulation of BMSCs may represent a novel therapeutic approach for glucocorticoid-induced osteoporosis.

Cui et al. (2025) studied this question.

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