Evaluation of Histological Response of Human Pulp to MTA as DPC Agent With LLLT-Split Mouth Randomised Controlled Trial.

This study examined the histological response of human dental pulp to Mineral Trioxide Aggregate (MTA) as a pulp-capping agent, with or without Low Level Laser Therapy (LLLT). Thirty-two premolars from 16 patients were treated in a split-mouth design: one side received MTA alone, the other MTA with diode laser-assisted haemostasis and decontamination. After 6 weeks, the teeth were extracted for histological analysis. Results showed that the group with LLLT had a higher incidence of complete dentine bridges (87.5% vs. 68.8%) and thicker bridges (> 0.25 mm: 81.3% vs. 68.8%), though differences were not statistically significant. Inflammation was significantly lower in the LLLT group, with all samples showing moderate inflammation compared to 68.8% in controls, and some severe inflammation cases. Tissue organisation was similar between groups. The study suggests that adding LLLT to MTA reduces pulpal inflammation and promotes more uniform, thicker dentine bridges, indicating improved pulp healing.