Analysis compares B cells in pediatric MOGAD patients with high MOG antibodies and seronegative individuals, suggesting heterogeneity in disease course.
Background/Purpose: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) constitutes a rare group of demyelinating disorders of the central nervous system, characterized by the presence of MOG antibodies (Abs) in serum. In pediatric patients, approximately 40% of affected individuals revert to MOG Ab seronegativity over time, indicating heterogeneity in disease course. The aim of this study was to investigate and compare MOG-specific memory B cells in two pediatric patient groups, patients with persistently high MOG Ab titres and patients who had become seronegative, and finally explore potential correlations with the disease course.
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Stephen et al. (2025) studied this question.
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