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September 28, 2025International Journal of Pharmaceutical Quality Assurance

The Role of Capillary Zone Electrophoresis in Hemoglobinopathy Diagnosis

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Authors

DDDilip K. DasVMVinaytosh MishraSASandeep K. Agarwal

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Overview

Evaluation of capillary electrophoresis identifies hemoglobin variants in individuals, highlighting the prevalence of beta thalassemia.

Key Points

  • Capillary zone electrophoresis identified hemoglobin variants in 7.85% of individuals, which is significant for diagnosis.
  • The study found 19.7% of subjects were beta thalassemia carriers with HbA2 levels ≥3.5%, indicating high prevalence.
  • Genetic tests confirmed that the most frequent mutation related to beta thalassemia was cd36-37(-T), particularly in this geographic region.
  • Blood samples and hemoglobin levels were evaluated using complete blood count (CBC) to support the detection of hemoglobinopathies.

Cite This Study

Das et al. (2025) studied this question.

synapsesocial.com/papers/68d90bc641e1c178a14f6e77https://doi.org/10.25258/ijpqa.16.5.01
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Laboratory features of hemoglobinopathies2024
  2. 215 years of hemoglobinopathies and thalassemias: from a textbook example in biochemistry to an everyday diagnostic challenge2026
  3. 3Comparison of High-Performance Liquid Chromatography and Capillary Electrophoresis in the Screening of Haemoglobinopathies2024
  4. 4Diagnosis of Hemoglobinopathies and thalassemias using both Haemoglobin capillary zone electrophoresis and High performance liquid chromatography - An experience from a tertiary care hospital in Northern India2024
  5. 5<b>15th National Congress of the Portuguese Society of Clinical Chemistry, Genetics and Laboratory Medicine</b>2024 · 5 citations