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September 28, 2025Molecular Ecology ResourcesOpen Access

A Near Telomere‐To‐Telomere Genome Assembly of Coffea arabica (Mundo Novo) Provides Insights Into Its Secondary Metabolism

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Authors

YLYi LiuHZHang ZongYXYaowu Xing

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Overview

Genome assembly reveals insights into secondary metabolism pathways in Coffea arabica, suggesting key roles for glycosyltransferases and N-methyltransferases.

Key Points

  • The high-quality genome assembly of Coffea arabica enhances understanding of its secondary metabolism, crucial for coffee production.
  • Using PacBio HiFi, Oxford Nanopore, and Hi-C sequencing technologies enabled the creation of the first T2T genome for Arabica coffee.
  • Phylogenetic analysis identified independent evolution of N-methyltransferases vital for caffeine production across species, including tea and cacao.
  • Glycosyltransferases showed a significant role in secondary metabolism, with functional characterization highlighting a novel pathway for sweetener production.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d90bc941e1c178a14f712ahttps://doi.org/10.1111/1755-0998.70053
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Also Consider

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  1. 1Coffea Comparative Genomics Reveals Subgenome-Associated Expansion and Diversification of Biosynthetic Gene Clusters2026
  2. 2THE PHARMACOLOGICAL AND THERAPEUTIC LANDSCAPE OF COFFEA ARABICA: A COMPREHENSIVE REVIEW2026
  3. 3Characterization of N-methyltransferase Genes in Coffea liberica var. liberica2024 · 1 citations
  4. 41H NMR-Based Metabolomics and Machine Learning Reveal Candidate Metabolic Markers Associated with Coffea arabica Genealogical Groups2026
  5. 5Genome association of carbohydrate metabolites provides new insights toward functional breeding in coffee2026