Observational analysis found that a single dose of salbutamol provides similar bronchodilator effects in children, suggesting no need for repeated doses.
Authors´ conclusions: the bronchodilator effect of a single inhaled dose of short action beta agonists with a valve holding chamber is similar to the administration of successive doses in children with mild acute asthma exacerbation. Reviewers´commentary: this study in children with mild asthmatic exacerbations, after a first effective dose of salbutamol, finds no short-term functional benefit in administering successive doses. There is no evidence in the longer-term impact or in other clinical variables. There is no data about the effect in more severe exacerbations neither in patients with partial response to a first dose of bronchodilator.
No takes yet. Share an insight, caveat, or question.
Atauri et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: