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September 28, 2025

Metabolic Cage Analysis of Surgically Catheterized C57BL/6J Mice (Mus musculus) Treated with Carprofen and Sustained-Release Buprenorphine.

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Authors

JTJack V. TuMSMarissa SaenzEBElizabeth Bloom-Saldana

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Overview

Metabolic analysis shows analgesia affects energy expenditure and activity levels in catheterized mice, suggesting careful consideration for study design.

Key Points

  • Catheterized mice treated with both carprofen and buprenorphine showed increased activity and food intake compared to controls.
  • During the first 12 hours post-surgery, these mice were 20% more active than sham mice given carprofen.
  • The study utilized metabolic cages for real-time monitoring of food consumption and energy expenditure.
  • Findings highlight the importance of considering analgesic effects in metabolic and behavioral research with mice.

Cite This Study

Tu et al. (2025) studied this question.

synapsesocial.com/papers/68d913ab4ddcf71ba560bd23https://doi.org/10.30802/aalas-jaalas-25-096
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Subcutaneous and orally self-administered high-dose carprofen shows favorable pharmacokinetic and tolerability profiles in male and female C57BL/6J mice2024 · 1 citations
  2. 2Carprofen and buprenorphine delivery using micropipette-guided drug administration (MDA) in mice2026
  3. 3Effects of orally administered metamizole, tramadol, and buprenorphine on postsurgical recovery in mice2026
  4. 4Pharmacokinetic Evaluation of a Topical Extended-release Analgesic in Mice2024 · 2 citations
  5. 5Refining pain management in mice by comparing multimodal analgesia and NSAID monotherapy for neurosurgical procedures2024 · 16 citations