September 28, 2025

Pharmacokinetic Evaluation of Topical Long-Acting Buprenorphine in New Zealand White Rabbits (Oryctolagus cuniculus).

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This trial assesses the pharmacokinetic parameters of topical buprenorphine in rabbits, indicating potential for improved analgesia.

Topical buprenorphine achieved significant plasma concentrations, exceeding 0.25 ng/mL within 30 minutes after dosing.
Healthy adult New Zealand white rabbits were administered varying doses of buprenorphine in a randomized crossover design.
Fecal and urinary output decreased for an average of 3.5 days post-dosing; food consumption was reduced for about 10 days.
Findings suggest buprenorphine is an effective, long-lasting analgesic for rabbits, warranting further study for optimal dosage.

Thi et al. (2025) studied this question.

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September 28, 2025

View Full Paper

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Authors

This trial assesses the pharmacokinetic parameters of topical buprenorphine in rabbits, indicating potential for improved analgesia.

Topical buprenorphine achieved significant plasma concentrations, exceeding 0.25 ng/mL within 30 minutes after dosing.
Healthy adult New Zealand white rabbits were administered varying doses of buprenorphine in a randomized crossover design.
Fecal and urinary output decreased for an average of 3.5 days post-dosing; food consumption was reduced for about 10 days.
Findings suggest buprenorphine is an effective, long-lasting analgesic for rabbits, warranting further study for optimal dosage.

Thi et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark