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September 28, 2025OncoImmunologyOpen Access

Natural killer cells in adoptive cell therapy: current landscape of genetic engineering strategies

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Authors

MBMaría BurónBioCruces Health research InstituteAEAnne EtxebarriaBioCruces Health research InstituteMÁMaite ÁlvarezBioCruces Health research Institute

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Implication

Review highlights the potential of genetically modified natural killer cells to enhance immunotherapy efficacy and safety.

Key Points

  • Natural killer cells show promise in cancer treatment, improving upon limitations faced by CAR-T cells in safety and efficacy.
  • Clinical benefits of NK cell therapies include reduced risk of cytokine release syndrome compared to traditional T-cell therapies.
  • Advances in genetic engineering of NK cells can mitigate challenges posed by the tumor microenvironment, enhancing therapeutic outcomes.
  • Current strategies involve both viral and non-viral genetic modifications, with ongoing clinical trials exploring their applications in immunotherapy.

Cite This Study

Burón et al. (2025) studied this question.

synapsesocial.com/papers/68d913b24ddcf71ba560c186https://doi.org/10.1080/2162402x.2025.2563099
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