September 28, 2025Cancer Research

Abstract B045: Breaking the Warburg code: RD3 redefines energetics in metastatic Neuroblastoma

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Discussion

Observational analysis highlights RD3's role in metabolic plasticity in neuroblastoma, suggesting new therapeutic avenues.

RD3 expression in metastatic neuroblastoma suppresses glycolysis and reprograms cellular metabolism, leading to modified tumor energetics.
A significant shift was observed in the metabolome with RD3 restoration, revealing alterations in 289 metabolites, predominantly in amino acid metabolism.
Assessment using metabolomics and mitostress tests confirmed that RD3 influences tumor cell metabolism across diverse neuroblastoma clones.
These findings underline RD3 as a potential metabolic gatekeeper in neuroblastoma, highlighting novel therapeutic vulnerabilities for intervention.

Subramanian et al. (2025) studied this question.

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