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September 29, 2025

Effects on Oral Squamous Carcinoma Cell Lines and Their Mechanisms of Pyrazole N-Aryl Sulfonate: A Novel Class of Selective Cyclooxygenase-2 Inhibitors.

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Authors

SWShiqi WangMSMingxuan ShiHWHuihui Wang

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Overview

This analysis shows that novel pyrazole N-aryl sulfonate compounds reduce OSCC growth and migration, indicating their promise as COX-2 inhibitors.

Key Points

  • Compounds 4b, 4d, and 5f significantly reduce cell proliferation and migration in OSCC cell lines.
  • These pyrazole derivatives induce apoptosis and inhibit COX-2 expression and its downstream targets.
  • The study utilized CCK-8, Transwell assays, and flow cytometry to evaluate effectiveness and mechanisms.
  • Potential targeted therapeutic application in OSCC highlights the lower cytotoxicity found in VERO cells.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68da58d1c1728099cfd10bbbhttps://doi.org/10.3390/ijms26188906
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