Digital pathology (DP) for the purpose of primary reads has emerged as a transformative tool in the practice of histopathology and has already proved to be suitable, bringing numerous advantages over traditional light microscopy (LM). This position paper promotes the adoption of DP, particularly whole slide imaging (WSI), within toxicologic pathology, emphasizing its applicability in Good Laboratory Practice (GLP)-compliant nonclinical safety assessments. With established benefits such as efficiency, remote collaboration, data security, and compatibility with artificial intelligence AI-based tools, DP represents a reliable and advanced alternative. This paper offers a counterpoint to recent skepticism expressed in the literature on the readiness of DP including discussion of implementation strategies, technical requirements, and the growing body of validation evidence supporting DP’s utility in toxicologic pathology.
Thoolen et al. (2025) studied this question.