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September 29, 2025Cancer Research

Abstract B013: Hepatocyte STAT3 signaling drives response to immunotherapy in pancreatic cancer

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Authors

JMJohn C. McVeyHCHeather CohoATAnna S. Thickens

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Overview

Orthotopic PDAC models show that hepatocyte IL6-STAT3 signaling impacts immunotherapy response, suggesting novel therapeutic targets.

Key Points

  • CKO mice treated with BG/CD40 exhibited improved survival compared to placebo, revealing the crucial role of STAT3 signaling.
  • Tumor-bearing mice demonstrated increased serum IL6 levels (339 pg/mL) and greater pSTAT3+ cell counts (2550 pSTAT3+ cells/mm2), indicating active liver inflammation.
  • Hepatocyte-specific STAT3 deletion reduced inflammatory gene expression to pre-tumor levels, highlighting the dependency of liver inflammation on STAT3 signaling.
  • Using anti-IL6 receptor treatment post-tumor implantation showed minimal effects, emphasizing the persistence of liver inflammation in PDAC.

Cite This Study

McVey et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd1136dhttps://doi.org/10.1158/1538-7445.pancreatic25-b013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A103: Targeting STAT3 in cancer-associated fibroblasts reprograms the stroma and enhances CD8+ T cell-mediated immunity in PDAC2025
  2. 2Abstract B041: Fibroblast STAT3 Signaling in Pancreatic Cancer: Implications for Immunotherapy and Tumor Microenvironment Modulation2024
  3. 3Abstract 4563: Small molecules inhibited dysregulated STAT3-proinflammatory axis and induced antitumor responses in pancreatic and breast cancer2026
  4. 4Abstract B044: Durable T-cell-mediated anti-tumor immune response to pancreatic cancer cells overexpressing interleukin 62024
  5. 5Abstract 5373: Decoding the role of intrinsic pancreatic cellular signaling in shaping the immunosuppressive tumor microenvironment2024