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September 29, 2025Cancer Research

Abstract A009: Characterizing the pre-metastatic liver in PDAC patients using scRNA-seq of FFPE tissue

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Authors

RHRichard L. HumphreyOtago PolytechnicAFAmy FletcherDuke Medical CenterJBJulia ButtonDuke Medical Center

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Implication

This analysis reveals distinct immune cell populations in the pre-metastatic liver of PDAC patients, indicating potential biomarkers for metastasis risk.

Key Points

  • Findings show distinct immune cell populations in the liver of PDAC patients, indicating unique disease characteristics.
  • Transcriptional analysis revealed disease state-specific expression patterns among immune and stromal populations in liver tissue.
  • This research utilized single-cell RNA sequencing to assess pre-metastatic liver environments, highlighting its scalability for diagnostics.
  • Enhanced understanding of the liver's microenvironment may improve early identification of patients at risk for metastasis.

Cite This Study

Humphrey et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd1137fhttps://doi.org/10.1158/1538-7445.pancreatic25-a009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A081: Dissecting the Tumor–Immune Landscape of PDAC Liver Metastases to Identify Candidate Drivers of Immune Evasion and Metastatic Outgrowth2025
  2. 2A platform for multisite immune profiling of premetastatic pancreatic cancer at single-cell resolution2025 · 2 citations
  3. 3Abstract B052: Single-cell and spatial analysis of the immune landscape unveils a subset of potentially tumor-reactive T cells in patients with localized PDAC2024
  4. 4Abstract A074: Integrated clinical and single-cell profiling analysis reveals cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma2024
  5. 5Abstract B046: Discovery of a fibroblast subtype enriched in long-term survivors of PDAC2025