September 29, 2025Cancer Research

Abstract B115: Integrated spatial and multi-omic analysis reveals functional niches in the pancreatic cancer microenvironment

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Identification of 83 distinct cell types and their states within the pancreatic cancer microenvironment, revealing critical functional interactions.
Patients in ECM-rich and immune-suppressed microenvironments had worse clinical outcomes, while immune-infiltrated regions linked to better survival.
The integrated methodology utilized single-cell RNA sequencing and multiplexed imaging mass cytometry across tissue samples to profile cellular landscapes.
These findings underscore the unique spatial ecosystems within the tumour microenvironment, indicating future therapeutic targets for pancreatic cancer.

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Implication

Integration of single-cell RNA sequencing and imaging mass cytometry reveals distinct tissue niches in pancreatic ductal adenocarcinoma, highlighting their impact on clinical outcomes.

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Shakfa et al. (2025) studied this question.

synapsesocial.com/papers/68da58dcc1728099cfd11395 https://doi.org/10.1158/1538-7445.pancreatic25-b115

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Implication

Integration of single-cell RNA sequencing and imaging mass cytometry reveals distinct tissue niches in pancreatic ductal adenocarcinoma, highlighting their impact on clinical outcomes.

Abstract B115: Integrated spatial and multi-omic analysis reveals functional niches in the pancreatic cancer microenvironment

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Discussion

Implication

Cite This Study

Abstract B115: Integrated spatial and multi-omic analysis reveals functional niches in the pancreatic cancer microenvironment

Key Points

Discussion

Implication

Cite This Study

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